منابع مشابه
UV damage, DNA repair and skin carcinogenesis.
Skin cancer is unique among human cancers in its etiology, accessibility and the volume of detailed knowledge now assembled concerning its molecular mechanisms of origin. The major carcinogenic agent for most skin cancers is well established as solar ultraviolet light. This is absorbed in DNA with the formation of UV-specific dipyrimidine photoproducts. These can be repaired by nucleotide excis...
متن کاملHsp90 Inhibitor Can Inhibit UV-Carcinogenesis
Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was as...
متن کاملCaffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.
Caffeic acid (3,4-dihydroxycinnamic acid) is a well-known phenolic phytochemical present in coffee and reportedly has anticancer activities. However, the underlying molecular mechanisms and targeted proteins involved in the suppression of carcinogenesis by caffeic acid are not fully understood. In this study, we report that caffeic acid significantly inhibits colony formation of human skin canc...
متن کاملSuppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.
Xeroderma pigmentosum (XP) patients are deficient in nucleotide excision repair (NER) because of mutations in one of the genes coding for NER enzymes. This results predominantly in high frequency of UV-induced skin tumors at an early age; the most severe phenotype is found in patients of complementation group A (XPA). However, in a subset of these XPA patients no skin tumors appear, even at adv...
متن کاملEffect of an extract of UV-irradiated linolenic acid on azo dye carcinogenesis.
One to four intraperitoneal injections of water extract of UV-irradiated linolenic acid were given to male Osborne Mendel rats. Injections were at monthly intervals with graded doses (120 to 600 thiobarbituric acid units/kg/dose) of the extract. Some of these rats received a subcarcinogenic dose (0. 1 2%) of p-dimethylaminoazobenzene (DAB) in powdered Purina chow diet from the day of first inje...
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ژورنال
عنوان ژورنال: Photochemistry and Photobiology
سال: 1984
ISSN: 0031-8655,1751-1097
DOI: 10.1111/j.1751-1097.1984.tb08872.x